Malave A, Yim G K
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
Life Sci. 1992;51(7):513-7. doi: 10.1016/0024-3205(92)90028-n.
Opioid peptides share the spasmogenic action of acutely administered morphine on the sphincter of Oddi. In this study, gallbladder function was assessed following chronic opioid administration. Implantation of morphine pellets (400 mg) in male guinea pigs depressed cholecystokinin-octapeptide(CCK)-induced emptying of gallbladder bile (monitored via a duodenal cannula). Gallbladder muscle strips, isolated from the morphine treated animals, showed depressed contractile responses to CCK. This antagonism was non-specific and indirectly mediated, as ACh contractions were also depressed, whereas CCK-induced contractions of gallbladder strips from untreated animals were unaffected by direct exposure to morphine (3 x 10(-6)M). The depression of CCK stimulation of bile flow by chronic morphine administration in male guinea pigs suggests that chronic exposure to opioids can impede gallbladder emptying.
阿片肽与急性给予吗啡时对Oddi括约肌的致痉挛作用相同。在本研究中，评估了长期给予阿片类药物后胆囊的功能。给雄性豚鼠植入吗啡丸（400毫克）会抑制胆囊收缩素八肽（CCK）诱导的胆囊胆汁排空（通过十二指肠插管监测）。从经吗啡处理的动物分离出的胆囊肌条对CCK的收缩反应降低。这种拮抗作用是非特异性的且由间接介导，因为乙酰胆碱的收缩也受到抑制，而未处理动物的胆囊条CCK诱导的收缩不受直接暴露于吗啡（3×10⁻⁶M）的影响。雄性豚鼠长期给予吗啡会抑制CCK对胆汁流动的刺激，这表明长期接触阿片类药物会阻碍胆囊排空。
