van den Berg Stéphanie M, Setiawan Adi, Bartels Meike, Polderman Tinca J C, van der Vaart Aad W, Boomsma Dorret I
Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, Amsterdam, The Netherlands.
Behav Genet. 2006 Mar;36(2):261-70. doi: 10.1007/s10519-005-9022-y. Epub 2006 Jan 12.
: We report heritabilities for individual differences in female pubertal development at the age of 12. Tanner data on breast and pubic hair development in girls and data on menarche were obtained from a total of 184 pairs of monozygotic and dizygotic twins. Genetic correlations were estimated to determine to what extent the same genes are involved in different aspects of physical development in puberty. A Bayesian estimation approach was taken, using Markov-chain Monte Carlo simulation to estimate model parameters. All three phenotypes were to a significant extent heritable and showed high genetic correlations, suggesting that a common set of genes is involved in the timing of puberty in general. However, gonadarche (menarche and breast development) and adrenarche (pubic hair) are affected by different environmental factors, which does not support the three phenotypes to be regarded as indicators of a unitary physiological factor.
我们报告了12岁女性青春期发育个体差异的遗传力。从总共184对同卵双胞胎和异卵双胞胎中获取了女孩乳房和阴毛发育的坦纳数据以及初潮数据。通过估计遗传相关性来确定在多大程度上相同的基因参与青春期身体发育的不同方面。采用贝叶斯估计方法，使用马尔可夫链蒙特卡罗模拟来估计模型参数。所有这三种表型在很大程度上都是可遗传的，并且显示出高度的遗传相关性，这表明一般来说，一组共同的基因参与青春期的时间进程。然而，性腺发育（初潮和乳房发育）和肾上腺发育（阴毛）受不同环境因素的影响，这并不支持将这三种表型视为单一生理因素的指标。
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