Xu Feng, Zhen Yong-Su, Shao Rong-Guang
Zhujiang Hospital, Southern Medical University, Guangzhou.
Sheng Li Ke Xue Jin Zhan. 2005 Oct;36(4):295-8.
Drug metabolism enzymes (DME) play a significant role in drug detoxification and activation, which exert important effect on drug efficacy and sensitivity to toxicity. There is difference in expression and activity of DME between in tumor tissue and in non-tumor tissue. DME related with tumor chemotherapy are cytochrome P450 (CYP), glutathione-S-transferase (GST), uridine diphospho-glucuronosyltransferase (UGT), thiopurine methyltransferase (TPMT) and dihydropyrimidine dehydrogenase (DPD). The enzymes above are inducible and genetic polymorphic, thus with variable activity in individuals.
药物代谢酶（DME）在药物解毒和激活过程中发挥着重要作用，这对药物疗效和毒性敏感性具有重要影响。肿瘤组织和非肿瘤组织中DME的表达和活性存在差异。与肿瘤化疗相关的DME包括细胞色素P450（CYP）、谷胱甘肽-S-转移酶（GST）、尿苷二磷酸葡萄糖醛酸基转移酶（UGT）、硫嘌呤甲基转移酶（TPMT）和二氢嘧啶脱氢酶（DPD）。上述酶具有诱导性和基因多态性，因此个体间活性存在差异。
