用于透皮给药系统制剂与开发的聚合松香评估：技术说明
Evaluation of polymerized rosin for the formulation and development of transdermal drug delivery system: a technical note.
作者信息
Satturwar Prashant M, Fulzele Suniket V, Dorle Avinash K
机构信息
Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, Nagpur-440033, India.
出版信息
AAPS PharmSciTech. 2005 Dec 27;6(4):E649-54. doi: 10.1208/pt060481.
Abstract
Results from the present study conclude that PR in combination with PVP and with incorporation of dibutyl phthalate (30% wt/wt) produces smooth flexible films with improved tensile strength and percentage elongation. The release rate of drug from films and permeation across skin increases with increase in drug and PVP loading but is independent of film thickness. Patches containing PR:PVP (7:3) show promise for pharmacokinetic and pharmacodynamic performance evaluation in a suitable animal model. In view of the overall results reported in the present study, it may be proposed that PR can be used in the design of a matrix type transdermal drug delivery system to prolong the drug release.
摘要
本研究结果表明，泼尼松龙（PR）与聚乙烯吡咯烷酮（PVP）联合使用并加入邻苯二甲酸二丁酯（30%重量/重量）可制成具有改善拉伸强度和伸长率的光滑柔性薄膜。药物从薄膜中的释放速率以及透过皮肤的渗透率随药物和PVP载药量的增加而增加，但与薄膜厚度无关。含有PR:PVP（7:3）的贴剂在合适的动物模型中显示出进行药代动力学和药效学性能评估的前景。鉴于本研究报告的总体结果，可能有人提出PR可用于设计基质型透皮给药系统以延长药物释放。
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