Fulzele S V, Satturwar P M, Dorle A K
Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, Nagpur 440010, India.
Int J Pharm. 2002 Dec 5;249(1-2):175-84. doi: 10.1016/s0378-5173(02)00529-x.
Polymerized rosin (PR) a novel film forming polymer is characterized and investigated in the present study for its application in drug delivery. Films were produced by a casting/solvent evaporation method from plasticizer free and plasticizer containing solutions. Films prepared from different formulations were studied for their mechanical (tensile strength, percent elongation and Young's modulus), water vapour transmission and moisture absorption characteristics. Neat PR films were slightly brittle and posed the problem of breaking during handling. Hydrophobic plasticizers, dibutyl sebacate and tributyl citrate, improved the mechanical properties of free films with both the plasticizers showing significant effects on film elongation. Release of diclofenac sodium (model drug) from coated pellets was sustained with high coating levels. Concentration of plasticizer was found to affect the release profile. PR films plasticized with hydrophobic plasticizers could therefore be used in coating processes for the design of oral sustained delivery dosage forms.
聚合松香（PR）是一种新型成膜聚合物，本研究对其在药物递送中的应用进行了表征和研究。通过流延/溶剂蒸发法，由不含增塑剂和含增塑剂的溶液制备薄膜。研究了由不同配方制备的薄膜的机械性能（拉伸强度、伸长率和杨氏模量）、水蒸气透过率和吸湿特性。纯PR薄膜稍脆，在处理过程中存在破裂问题。疏水性增塑剂癸二酸二丁酯和柠檬酸三丁酯改善了无增塑剂薄膜的机械性能，两种增塑剂对薄膜伸长率均有显著影响。双氯芬酸钠（模型药物）从包衣微丸中的释放具有高包衣水平的缓释效果。发现增塑剂浓度会影响释放曲线。因此，用疏水性增塑剂增塑的PR薄膜可用于口服缓释剂型设计的包衣工艺。
