Zhang Hongjun, Padwa Albert
Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA.
Org Lett. 2006 Jan 19;8(2):247-50. doi: 10.1021/ol052524f.
[reaction: see text] A highly efficient total synthesis of (+/-)-Lycoricidine is described. The synthesis features the ready preparation of the Lycoricidine skeleton by a Stille-IMDAF cycloaddition cascade. The resulting cycloadduct is then used for the stereocontrolled installation of the other functionality present in the C-ring of the target molecule.
[反应:见正文] 描述了(±)-石蒜碱的高效全合成。该合成的特点是通过Stille-IMDAF环加成串联反应轻松制备石蒜碱骨架。然后将所得的环加成产物用于立体控制地安装目标分子C环中存在的其他官能团。