Metal coordination-directed hydroxylation of steroids with a novel artificial P-450 catalyst.
作者信息
Fang Zhenglai, Breslow Ronald
机构信息
Department of Chemistry, Columbia University, New York, New York 10027, USA.
出版信息
Org Lett. 2006 Jan 19;8(2):251-4. doi: 10.1021/ol052589i.
Abstract
[structure: see text] A novel catalyst has been synthesized in which a manganese-porphyrin unit is linked to two 2,2'-bipyridyl groups and two pentafluorophenyl groups in trans fashion on its four meso positions. Relative to a previous catalyst in which the manganese-porphyrin had four 2,2'-bipyridyl groups, the new catalyst, in the presence of Cu(2+) ions as coordinating linkers, catalyzes the oxidation of a steroid substrate with much better regioselectivity and higher turnover numbers.
摘要
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本文引用的文献
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Selective Hydroxylation of a Steroid at C-9 by an Artificial Cytochrome P-450 We thank the National Institutes of Health, the National Science Foundation, and the Environmental Protection Agency for financial support of this research. J.Y. acknowledges support from an NCERQA EPA Graduate Fellowship and a Bristol-Myers Squibb Graduate Fellowship.
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