Lee Hwansung, Taenaka Yoshiyuki, Kitamura Soichro
Department of Artificial Organs, Research Institute, National Cardiovascular Center, Suita, Osaka, Japan.
Artif Organs. 2006 Jan;30(1):16-23. doi: 10.1111/j.1525-1594.2006.00175.x.
The purpose of this study was to establish a method for estimating mechanical in vitro heart valve cavitation in an electro-hydraulic total artificial heart (EHTAH). The variations in the left driving pressure (LDP) slope of the EHTAH were used as an index of the cavitation intensity. The LDP slope was controlled by changing the stroke volume of the EHTAH. The stroke volume was changed from full-filling and full-eject to partial-filling and partial-eject conditions. A 25-mm Medtronic Hall valve was installed in the mitral position of the EHTAH. Cavitation bubbles were concentrated on the valve stop; the major cause of these cavitation bubbles was determined to be squeeze flow. The valve-closing velocity was found to be proportional to increases in the LDP slope and the stroke volume of the left blood pump. The cavitation intensity and the cavitation event rate increased with increases in the stroke volume of the EHTAH. A consistent correlation was observed between the valve-closing velocity and the cavitation intensity. The LDP slope of the EHTAH may play an important role in estimating the mechanical heart valve cavitation intensity.
本研究的目的是建立一种方法，用于评估电动液压全人工心脏（EHTAH）中机械体外心脏瓣膜的空化情况。EHTAH左驱动压力（LDP）斜率的变化被用作空化强度的指标。通过改变EHTAH的 stroke volume来控制LDP斜率。stroke volume从全充盈和全射血状态改变为部分充盈和部分射血状态。在EHTAH的二尖瓣位置安装了一个25毫米的美敦力霍尔瓣膜。空化气泡集中在瓣膜止动处；这些空化气泡的主要原因被确定为挤压流。发现瓣膜关闭速度与LDP斜率和左血泵的stroke volume增加成正比。随着EHTAH的stroke volume增加，空化强度和空化事件发生率也增加。在瓣膜关闭速度和空化强度之间观察到一致的相关性。EHTAH的LDP斜率可能在估计机械心脏瓣膜空化强度方面发挥重要作用。 （注：原文中“stroke volume”直译为“搏出量”，这里为保留原文表述未做修改）
