Cardoso Raquel, Freitas João Duarte, Reis José Pedro, Tellechea Oscar
Department of Dermatology, University Hospital, Coimbra, Portugal.
Dermatol Online J. 2005 Dec 1;11(3):37.
Cysts of the median raphe are uncommon. We describe a 43-year-old man with an asymptomatic nodule on the glans penis. Excision of the lesion was performed followed by histological and immunohistochemical studies. Histopathological examination revealed a solitary unilocular cystic cavity in the corium, lined by a pseudostratified columnar epithelium, among which mucinous cells where identified. Hints of decapitation secretion occurred at the apex of the luminal layer. An immunohistochemical study using a standard avidin-biotin peroxidase method disclosed CK7 and CK13 reactivity in the columnar cells. Epithelial membrane antigen (EMA) and carcinoembryonic (CEA) antigen immunoreactivity occurred at the apical border of the luminal cells. No staining was obtained with anti-CK20, human milk fat globulin 1 (HMFG1) and anti- S100 protein. The study supports its histogenetic relationship with the urothelium.
中缝囊肿并不常见。我们描述了一名43岁男性，其阴茎头有一个无症状结节。对该病变进行了切除，随后进行了组织学和免疫组织化学研究。组织病理学检查显示真皮内有一个孤立的单房性囊腔，内衬假复层柱状上皮，其中可见黏液细胞。在管腔层顶端有断头分泌的迹象。使用标准抗生物素蛋白-生物素过氧化物酶方法进行的免疫组织化学研究显示柱状细胞中有细胞角蛋白7（CK7）和细胞角蛋白13（CK13）反应性。上皮膜抗原（EMA）和癌胚抗原（CEA）免疫反应出现在管腔细胞的顶端边界。抗细胞角蛋白20（CK20）、人乳脂肪球蛋白1（HMFG1）和抗S100蛋白均未染色。该研究支持其与尿路上皮的组织发生关系。
