[电针治疗对不稳定膀胱大鼠膀胱颈和逼尿肌中氮能神经递质的影响]
[Effects of electroacupuncture treatment on nitrergic neurotransmitter in bladder neck and detrusor of rats with unstable bladder].
作者信息
Chen Yue-Lai, Cen Jue, Hou Wen-Guang, Gao Zhi-Qiang, Yu Xian-Min, Ma Xue-Mei
机构信息
Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
出版信息
Zhong Xi Yi Jie He Xue Bao. 2006 Jan;4(1):73-5.
OBJECTIVE
To observe the effects of electroacupuncture treatment on nitrergic neurotransmitter in bladder neck and detrusor of rats with unstable bladder.
METHODS
Rat models of unstable bladder were established by operation to induce urethral obstruction. Electroacupuncture treatment was given by acupuncturing Huiyang and Zhonglushu points for a week. Then the neuronal nitric oxide synthase (nNOS)-, endothelial nitric oxide synthase (eNOS)- and inducible nitric oxide synthase (iNOS)-positive cells in bladder neck and detrusor of the rats were observed.
RESULTS
The nitrergic neurotransmitter in bladder neck and detrusor were obviously decreased in rats with unstable bladder. The electroacupuncture treatment could significantly increase the contains of NOS in bladder tissue.
CONCLUSION
To promote the synthesis and secretion of nitrergic neurotransmitter in bladder tissue may be one of the mechanisms of acupuncture in adjusting bladder function.
目的
观察电针治疗对不稳定膀胱大鼠膀胱颈和逼尿肌中含氮能神经递质的影响。
方法
通过手术诱导尿道梗阻建立不稳定膀胱大鼠模型。针刺会阳穴和中膂俞穴进行电针治疗，为期一周。然后观察大鼠膀胱颈和逼尿肌中神经元型一氧化氮合酶（nNOS）、内皮型一氧化氮合酶（eNOS）和诱导型一氧化氮合酶（iNOS）阳性细胞。
结果
不稳定膀胱大鼠膀胱颈和逼尿肌中的含氮能神经递质明显减少。电针治疗可显著增加膀胱组织中一氧化氮合酶的含量。
结论
促进膀胱组织中含氮能神经递质的合成与分泌可能是针刺调节膀胱功能的机制之一。
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