Carne Ross P, Vogrin Simon, Litewka Lucas, Cook Mark J
Victorian Epilepsy Centre at St. Vincent's Hospital, University of Melbourne, Melbourne, Australia.
J Clin Neurosci. 2006 Jan;13(1):60-72. doi: 10.1016/j.jocn.2005.02.013.
The aim of the present study was to examine quantitative differences in lobar cerebral cortical volumes in a healthy adult population. Quantitative volumetric MRI of whole brain, cerebral and cerebellar volumes was performed in a cross-sectional analysis of 97 normal volunteers, with segmented frontal, temporal, parietal and occipital cortical volumes measured in a subgroup of 60 subjects, 30 male and 30 female, matched for age and sex. The right cerebral hemisphere was larger than the left across the study group with a small (<1%) but significant difference in symmetry (P<0.001). No difference was found between volumes of right and left cerebellar hemispheres. Rightward cerebral cortical asymmetry (right larger than left) was found to be significant across all lobes except parietal. Males had greater cerebral, cerebellar and cerebral cortical lobar volumes than females. Larger male cerebral cortical volumes were seen in all lobes except for left parietal. Females had greater left parietal to left cerebral hemisphere and smaller left temporal to left cerebral hemisphere ratios. There was a mild reduction in cerebral volumes with age, more marked in males. This study confirms and augments past work indicating underlying structural asymmetries in the human brain, and provides further evidence that brain structures in humans are differentially sensitive to the effects of both age and sex.
本研究的目的是检测健康成年人群大脑各叶皮质体积的定量差异。对97名正常志愿者进行了全脑、大脑和小脑体积的定量容积磁共振成像横断面分析，在60名年龄和性别匹配的受试者（30名男性和30名女性）亚组中测量了额叶、颞叶、顶叶和枕叶皮质体积。在整个研究组中，右侧大脑半球比左侧大，对称性存在微小（<1%）但显著的差异（P<0.001）。左右小脑半球体积未发现差异。除顶叶外，在所有脑叶中均发现右侧大脑皮质不对称（右侧大于左侧）显著。男性的大脑、小脑和大脑皮质叶体积大于女性。除左侧顶叶外，在所有脑叶中均观察到男性大脑皮质体积较大。女性的左侧顶叶与左侧大脑半球的比例较大，而左侧颞叶与左侧大脑半球的比例较小。随着年龄增长，大脑体积有轻度减小，在男性中更为明显。本研究证实并扩展了以往表明人类大脑存在潜在结构不对称的研究工作，并进一步证明人类大脑结构对年龄和性别的影响具有不同的敏感性。
