Caverzasio J, Bonjour J P
Nephrologie. 1992;13(3):109-13.
Inorganic phosphate (Pi) is an essential determinant of cellular growth and replication. IGF-1, a growth hormone dependent factor, enhances at the kidney level both the tubular reabsorption of inorganic phosphate (Pi) and the production of 1,25-dihydroxyvitamin D3. Through these two renal actions IGF-1 increases the extracellular concentration of Pi. Consequently, the amount of Pi available for cellular growth and bone mineral deposition is maintained at a higher level as compared to the concentration prevailing during the adult life. Thus, IGF-1 appears to play a pivotal role in the control of Pi economy, particularly during growth.
无机磷酸盐（Pi）是细胞生长和复制的重要决定因素。胰岛素样生长因子-1（IGF-1）是一种依赖生长激素的因子，在肾脏水平上增强无机磷酸盐（Pi）的肾小管重吸收以及1,25-二羟基维生素D3的生成。通过这两种肾脏作用，IGF-1增加了细胞外Pi的浓度。因此，与成年期的普遍浓度相比，可用于细胞生长和骨矿物质沉积的Pi量维持在更高水平。因此，IGF-1似乎在Pi代谢的控制中起关键作用，尤其是在生长期间。
