Boothroyd Clare, Yazdani Anusch
Greenslopes Specialist Centre, Brisbane, Queensland, Australia.
Fertil Steril. 2006 Jan;85(1):227. doi: 10.1016/j.fertnstert.2005.06.052.
To describe the first reported cases of two women with polycystic ovary syndrome (PCOS) desirous of pregnancy who conceived trichorionic pregnancies following ovulation induction with metformin alone and metformin plus clomiphene.
Case report.
Private fertility practice.
PATIENT(S): Two women with polycystic ovary syndrome, one lean and one overweight, both oligoovulatory and not undertaking their first cycle of treatment.
INTERVENTION(S): Ovulation induction by metformin alone or in combination with clomiphene
MAIN OUTCOME MEASURE(S): Higher-order multiple pregnancy (triplet or greater).
RESULT(S): Two cases of trichorionic pregnancy.
CONCLUSION(S): This is the first report of higher-order multiple pregnancies resulting from the use of either metformin alone or in combination with clomiphene. The additive effects of adjunctive treatments such as weight reduction, ovarian drilling, and clomiphene and metformin therapy may result in an increased incidence of higher-order multiple pregnancy and women need to be counseled about this risk. Further research is required to quantify the risk of this event per treatment cycle.
描述首例报道的两名患有多囊卵巢综合征（PCOS）且渴望怀孕的女性，她们在单独使用二甲双胍以及二甲双胍加克罗米芬诱导排卵后怀上了三绒毛膜妊娠。
病例报告。
私人不孕不育诊所。
两名患有多囊卵巢综合征的女性，一名体型偏瘦，一名超重，均为排卵稀少且并非首次接受治疗周期。
单独使用二甲双胍或与克罗米芬联合诱导排卵
高阶多胎妊娠（三胞胎或更多）。
两例三绒毛膜妊娠。
这是首例关于单独使用二甲双胍或与克罗米芬联合使用导致高阶多胎妊娠的报道。诸如减重、卵巢打孔以及克罗米芬和二甲双胍治疗等辅助治疗的累加效应可能会导致高阶多胎妊娠的发生率增加，需要就此风险向女性提供咨询。需要进一步研究来量化每个治疗周期发生此事件的风险。
