Donnelly R, Elliott H L, Meredith P A
Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, U.K.
Pharmacol Ther. 1992;53(1):67-79. doi: 10.1016/0163-7258(92)90044-z.
Individualized approaches to antihypertensive therapy are being widely advocated. Ideally these should incorporate rational prospective methods for drug and dosage selection but progress has been hampered by the paucity of information about dose- (and plasma concentration-) response relationships. However, in several recent clinical studies, concentration-effect analysis has been used to characterize kinetic-dynamic relationships in individual patients for a range of antihypertensive drugs. This approach provides an integrated mathematical description of drug response which has potential utility for quickly identifying poor or nonresponders and for determining individual dose requirements for optimum longterm blood pressure control.
目前广泛提倡采用个体化抗高血压治疗方法。理想情况下，这些方法应纳入合理的前瞻性药物和剂量选择方法，但由于关于剂量（和血浆浓度）-反应关系的信息匮乏，进展受到了阻碍。然而，在最近的几项临床研究中，浓度-效应分析已被用于描述一系列抗高血压药物在个体患者中的动力学-动态关系。这种方法提供了药物反应的综合数学描述，对于快速识别反应不佳或无反应者以及确定个体最佳长期血压控制所需剂量具有潜在的实用价值。
