In vitro availability of glibenclamide in presence of antacids.

The in vitro availability studies of glibenclamide in presence of commonly used antacids are present in this paper. Glibenclamide is used for the treatment of Non-Insulin dependent diabetes mellitus. It is a sulfonylurea derivative. Antacids are prescribed to encounter gastric acidity etc. These studies were carried out in simulated gastric juice and in buffer of pH 7.4 at 37 and 48 degrees C. Aluminum hydroxide, aluminum trisilicate, magnesium oxide, magnesium trisilicate, sodium bicarbonate, calcium carbonate, magaldrate and simethicone (2,4-dimethoxypolysiloxane) antacids were used in these studies. It has been observed that in case of magnesium oxide, magnesium trisilicate and sodium bicarbonate, availability of glibenclamide was enhanced while in rest of the antacids retarded the availability of glibenclamide.