Kharlamov V T, Inkin A A, Ermolina G E
Antibiotiki. 1975 Feb;20(2):99-102.
Penaldinic acid and penicillamine were formed on alkali decomposition (1 N NaOH) of 6-APA for 20 minutes at room temperature, penicillamine being completely oxidized to disulphide by the air oxygen. Coulometric titration of the alkali decomposition products showed that generated chlorine in 0.5 N HCl solution or bromine in a week acid solution of KBr oxidized them with participation of 7 electrones. Generated iodine did not practically oxidize the 6-APA decomposition products during the coulometric titration.
在室温下，6-氨基青霉烷酸（6-APA）用1N氢氧化钠进行碱分解20分钟后生成青霉烷酸和青霉胺，青霉胺会被空气中的氧气完全氧化成二硫化物。对碱分解产物进行库仑滴定表明，在0.5N盐酸溶液中产生的氯或在溴化钾的弱酸溶液中产生的溴，在7个电子参与下将它们氧化。在库仑滴定过程中，产生的碘实际上不会氧化6-APA的分解产物。
