Weber Christina, Weninger Manfred, Klebermass Katrin, Reiter Gernot, Wiesinger-Eidenberger Gabriele, Brandauer Mathias, Kraschl Raimund, Lingitz Karl, Grassl-Jurek Renate, Sterniste Walter, Balluch Bernd, Kolmer Micha, Bruckner Robert, Schweintzger Gerolf, Salzer Hans, Rath Irene, Kubitsch Peter, Zissler Werner, Müller Wilhelm, Urlesberger Berndt
Division of Neonatology, Department of Pediatrics, Medical University of Graz, Graz, Austria.
Wien Klin Wochenschr. 2005 Nov;117(21-22):740-6. doi: 10.1007/s00508-005-0468-y.
The aim of this retrospective study was to analyze the mortality and morbidity for extremely preterm infants with a gestational age from 22 to 26 weeks. All infants were born in Austria during the years 1999-2001.
Data were collected from 16 neonatal intensive care units in Austria. Main outcome criteria were mortality, the rates of chronic lung disease (CLD) and severe retinopathy of prematurity (ROP, stage > or =3) to determine the short-term outcome; the rate of cerebral palsy (CP) at the corrected age of twelve months to assess the long-term outcome.
Overall, 796 preterm infants with a gestational age less than 27 weeks were born in Austria and 581 (73%) were registered as live-born infants. Of those live born, 508 (87%) were analyzed. The mortality rates were 83%, 76%, 43%, 26% and 13% for 22, 23, 24, 25 and 26 weeks' gestation, respectively. The rates of CLD were 33% (22 weeks), 36% (23 weeks), 42% (24 weeks), 31% (25 weeks) and 22% (26 weeks). The rates of ROP of stage > or =3 were 0% (22 weeks), 29% (23 weeks), 23% (24 weeks), 18% (25 weeks) and 10% (26 weeks). The rates of CP at the corrected age of 12 months were 33%, 50%, 33%, 26% and 25% for 22, 23, 24, 25 and 26 weeks' gestation, respectively.
The results of this national study are in accordance with the international literature: mortality and morbidity increased with decreasing gestational age.
本回顾性研究旨在分析孕龄为22至26周的极早产儿的死亡率和发病率。所有婴儿均于1999年至2001年期间在奥地利出生。
从奥地利的16个新生儿重症监护病房收集数据。主要结局标准为死亡率、慢性肺病（CLD）发生率和重度早产儿视网膜病变（ROP，≥3期）发生率，以确定短期结局；12个月校正年龄时的脑瘫（CP）发生率，以评估长期结局。
总体而言，奥地利有796名孕龄小于27周的早产儿出生，其中581名（73%）登记为活产婴儿。在这些活产婴儿中，508名（87%）接受了分析。孕22、23、24、25和26周时的死亡率分别为83%、76%、43%、26%和13%。CLD发生率分别为33%（22周）、36%（23周）、42%（24周）、31%（25周）和22%（26周）。ROP≥3期的发生率分别为0%（22周）、29%（23周）、23%（24周）、18%（25周）和10%（26周）。孕22、23、24、25和26周时，12个月校正年龄时的CP发生率分别为33%、50%、33%、26%和25%。
这项全国性研究的结果与国际文献一致：死亡率和发病率随孕龄降低而增加。
