Modi Seema, Lowder Dionne M
Department of Family Medicine, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834, USA.
Am Fam Physician. 2006 Jan 1;73(1):72-8.
Sufficient evidence and consensus exist to recommend propranolol, timolol, amitriptyline, divalproex, sodium valproate, and topiramate as first-line agents for migraine prevention. There is fair evidence of effectiveness with gabapentin and naproxen sodium. Botulinum toxin also has demonstrated fair effectiveness, but further studies are needed to define its role in migraine prevention. Limited evidence is available to support the use of candesartan, lisinopril, atenolol, metoprolol, nadolol, fluoxetine, magnesium, vitamin B2 (riboflavin), coenzyme Q10, and hormone therapy in migraine prevention. Data and expert opinion are mixed regarding some agents, such as verapamil and feverfew; these can be considered in migraine prevention when other medications cannot be used. Evidence supports the use of timed-release dihydroergotamine mesylate, but patients should be monitored closely for adverse effects.
有充分的证据和共识推荐普萘洛尔、噻吗洛尔、阿米替林、丙戊酸二钠、丙戊酸钠和托吡酯作为预防偏头痛的一线药物。有合理证据表明加巴喷丁和萘普生钠有效。肉毒杆菌毒素也已证明有一定疗效，但需要进一步研究来确定其在预防偏头痛中的作用。支持坎地沙坦、赖诺普利、阿替洛尔、美托洛尔、纳多洛尔、氟西汀、镁、维生素B2（核黄素）、辅酶Q10和激素疗法用于预防偏头痛的证据有限。关于某些药物，如维拉帕米和小白菊，数据和专家意见不一；当无法使用其他药物时，可考虑将这些药物用于预防偏头痛。有证据支持使用甲磺酸二氢麦角胺缓释剂，但应密切监测患者的不良反应。
