Liu Dabo, Chen Qian, Huang Zhenyun, Zhong Jianwen, Zhou Lifeng
Department of Otolaryngology, Pediatric Hospital, Guangzhou, 510120, China.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Oct;19(19):868-70.
To explore the characteristics of auditory brainstem response(ABR) in severe obstructive sleep apnea-hypopnea syndrome.
ABR was recorded in 37 severe OSAHS patients (OSAHS group) and 20 controls.
(1) In the OSAHS group, the latency values of waves I, III and V were (1.67+/-0.20) ms, (3.87+/-0.31) ms, (5.70+/-0.31) ms respectively. In the control group, the latency values of waves I, III and V were (1.60+/-0.11) ms, (3.81+/-0.23) ms, (5.61+/-0.23) ms respectively. A statistically significant prolongation was found in the latency values of waves I in OSAHS group compared to control group (P < 0.05). (2) When comparing to the control group, the transmission time between waves III and V was found to be prolonged and waves I and III to be shortened in the OSAHS group. Furthermore, the change was considered statistically significant (P <0.05). (3) A statistically significant elevation was found in response threshold of wave V when comparing to the control group (P < 0.05).
The pathological sleepiness seen in OSAHS patients may cause ABR abnormalities, as a consequence of the chronic hypoxic and hypercapnic status occurring in the brain-stem and cochlear.
探讨重度阻塞性睡眠呼吸暂停低通气综合征患者听觉脑干反应（ABR）的特征。
对37例重度阻塞性睡眠呼吸暂停低通气综合征患者（OSAHS组）和20例对照组进行ABR检测。
（1）OSAHS组中，Ⅰ、Ⅲ、Ⅴ波潜伏期分别为（1.67±0.20）ms、（3.87±0.31）ms、（5.70±0.31）ms；对照组中，Ⅰ、Ⅲ、Ⅴ波潜伏期分别为（1.60±0.11）ms、（3.81±0.23）ms、（5.61±0.23）ms。与对照组相比，OSAHS组Ⅰ波潜伏期有统计学意义的延长（P<0.05）。（2）与对照组相比，OSAHS组Ⅲ、Ⅴ波间期延长，Ⅰ、Ⅲ波间期缩短，差异有统计学意义（P<0.05）。（3）与对照组相比，OSAHS组Ⅴ波反应阈有统计学意义的升高（P<0.05）。
OSAHS患者的病理性嗜睡可能由于脑干和耳蜗的慢性缺氧和高碳酸血症导致ABR异常。
