Jochman Kimberly A, Newman Sarah M, Kalin Ned H, Bakshi Vaishali P
Department of Surgery, University of Wisconsin-Madison, Madison, WI 53719, USA.
Behav Neurosci. 2005 Dec;119(6):1448-58. doi: 10.1037/0735-7044.119.6.1448.
Corticotropin-releasing factor (CRF) receptor activation within the basolateral amygdala (BLA) has been relatively unexplored compared with the central nucleus of the amygdala (CeA), despite the fact that CRF receptors are more densely distributed in BLA than in CeA. The authors show that infusion of CRF into BLA, but not CeA, decreases feeding and increases grooming. These effects are mediated by CRF-sub-1 receptors, because they are blocked by intra-BLA treatment with NBI27914 (NBI), a CRF-sub-1 antagonist, but not Astressin 2B, a CRF-sub-2 antagonist. Exposure to a stressor results in behaviors identical to those seen after intra-BLA CRF infusion. These stress-induced changes are prevented by pre-stress treatment with NBI but not Astressin 2B. These data demonstrate that stimulation of intra-BLA CRF-sub-1 receptors is both necessary and sufficient for eliciting stress-induced anorexia and grooming.
与杏仁核中央核（CeA）相比，基底外侧杏仁核（BLA）内促肾上腺皮质激素释放因子（CRF）受体的激活情况相对较少受到研究，尽管事实上CRF受体在BLA中的分布比在CeA中更为密集。作者表明，向BLA而非CeA中注入CRF会减少进食并增加梳理行为。这些效应由CRF-1受体介导，因为它们会被BLA内注射CRF-1拮抗剂NBI27914（NBI）所阻断，但不会被CRF-2拮抗剂Astressin 2B所阻断。暴露于应激源会导致与BLA内注射CRF后所观察到的行为相同的行为。这些应激诱导的变化可通过应激前用NBI而非Astressin 2B进行预处理来预防。这些数据表明，刺激BLA内的CRF-1受体对于引发应激诱导的厌食和梳理行为既必要又充分。
