Schweimer Judith, Saft Simone, Hauber Wolfgang
Department of Animal Psysiology, Biological Institute, University of Stuttgart, Stuttgart, Germany.
Behav Neurosci. 2005 Dec;119(6):1687-92. doi: 10.1037/0735-7044.119.6.1687.
This study examined whether catecholamine-mediated signals in the anterior cingulate cortex (ACC) contribute to effort-based decision making. Rats were tested after 6-hydroxydopamine or vehicle infusions into the ACC in a T maze cost-benefit task in which the rats could choose either to climb a barrier to obtain a high reward in one arm or run into the other arm without a barrier to obtain a low reward. Results demonstrate that infusions of 6-hydroxydopamine induced a near total loss of tyrosine hydroxylase-positive fibers in the ACC. Unlike sham-lesioned rats, 6-hydroxydopamine-lesioned rats exhibited a reduced preference for the high-cost-high-reward response option when given the choice of obtaining a low reward with little effort. Thus, catecholamine-mediated signals in the ACC could play a role in effort-based decision making.
本研究考察了前扣带皮层（ACC）中儿茶酚胺介导的信号是否有助于基于努力的决策。在大鼠的前扣带皮层注入6-羟基多巴胺或赋形剂后，在T迷宫成本效益任务中对其进行测试。在该任务中，大鼠可以选择攀爬障碍物以在一侧臂获得高奖励，或者进入另一侧无障碍物的臂以获得低奖励。结果表明，注入6-羟基多巴胺导致前扣带皮层中酪氨酸羟化酶阳性纤维几乎完全丧失。与假手术大鼠不同，6-羟基多巴胺损伤的大鼠在有机会轻松获得低奖励时，对高成本高回报反应选项的偏好降低。因此，前扣带皮层中儿茶酚胺介导的信号可能在基于努力的决策中发挥作用。
