Nuin Paulo A S
Division of Genomics and Proteomics in Cancer, Ontario Cancer Institute, University Health Network, 620 University Ave, Toronto, ON, Canada M5G 2M9.
Brief Bioinform. 2005 Dec;6(4):390-3. doi: 10.1093/bib/6.4.390.
The curriculum for genetics courses is shifting from a classical to a more molecular genetics focus, increasing the importance of subjects such as population genetics. Population genetics is a computational and statistical field that requires a good understanding of the nature of stochastic events. It is a difficult field for biology students with a limited mathematical background and there is a need for visualisation tools to facilitate understanding by the use of practical examples. WinPop provides students and researchers with a visual tool to allow the simulation and representation of population genetics phenomena. WinPop is a user-friendly software meant for use in population genetics courses and basic research. WinPop 2.5 contains six different modules that represent and simulate population genetics models. Genotype and allele frequencies are calculated under the different models: panmixia, genetic drift, assortative matings, selection, gene flow and mutation. The program's interface presents information in Cartesian graphics and isosceles triangular coordinate systems, allowing the user to save graphical and textual data output from the simulations. WinPop is developed in Visual Basic 6.0 and uses Windows 95 and higher. WinPop 2.5 can be downloaded from http://www.genedrift.org/winpop.php.
遗传学课程的教学大纲正在从经典遗传学转向更加聚焦分子遗传学,这使得群体遗传学等学科的重要性日益增加。群体遗传学是一个计算和统计领域,需要对随机事件的本质有很好的理解。对于数学背景有限的生物学专业学生来说,这是一个困难的领域,因此需要可视化工具,通过实际例子来帮助理解。WinPop为学生和研究人员提供了一个可视化工具,用于模拟和展示群体遗传学现象。WinPop是一款用户友好型软件,适用于群体遗传学课程和基础研究。WinPop 2.5包含六个不同的模块,用于表示和模拟群体遗传学模型。在不同模型下计算基因型和等位基因频率:随机交配、遗传漂变、选型交配、选择、基因流和突变。该程序的界面以笛卡尔图形和等腰三角形坐标系呈现信息,允许用户保存模拟输出的图形和文本数据。WinPop是用Visual Basic 6.0开发的,使用Windows 95及更高版本。WinPop 2.5可从http://www.genedrift.org/winpop.php下载。