Hattori N, Ikekubo K, Ishihara T, Moridera K, Hino M, Kurahachi H
Department of Endocrinology, Kobe City General Hospital, Japan.
Acta Endocrinol (Copenh). 1992 Jun;126(6):497-500. doi: 10.1530/acta.0.1260497.
We present the case of a normal ovulatory woman with marked hyperprolactinemia and no evidence of a pituitary adenoma on CT and MRI. Gel filtration studies showed that most immunoreactive PRL was eluted as 150K-170K macroprolactin. Anti-PRL autoantibody was detected and Scatchard analysis revealed a low-affinity (the association constant: 1.29 x 10(7) l/mol), high-capacity (the maximal binding capacity: 1174 micrograms/l) antibody. Dopamine had little suppressive effect on PRL levels and an antidopaminergic agent elicited an augmented response of PRL secretion. These results suggest that the presence of anti-PRL autoantibody may delay the clearance of PRL and/or may alter the central regulation of PRL secretion.
我们报告一例排卵正常但催乳素显著升高的女性病例，CT和MRI检查未发现垂体腺瘤证据。凝胶过滤研究显示，大多数免疫反应性催乳素以150K - 170K大催乳素形式洗脱。检测到抗催乳素自身抗体，Scatchard分析显示为低亲和力（结合常数：1.29×10⁷ l/mol）、高容量（最大结合容量：1174微克/升）抗体。多巴胺对催乳素水平几乎没有抑制作用，而抗多巴胺能药物可引发催乳素分泌增强反应。这些结果表明，抗催乳素自身抗体的存在可能会延迟催乳素的清除和/或改变催乳素分泌的中枢调节。
