Dong Cunhai, Duan Bin, Yuan Xiaoyan, Yao Kangde
School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2005 Dec;22(6):1245-8.
Ultrafine poly (D, L-lactide) (PLA) fibers with diameter less than 200 nm produced by electrospinning were studied to obtain tissue restoration resembling extracellular matrix. Scanning electron microscopy was used to observe the fiber morphology. Results showed that the solvent was the critical factor to determine the formation of the electrospun PLA fibers. Compared with acetone, N,N-dimethylformamide (DMF) was a better solvent for PLA to electrospin. Entrance of an organic salt, triethylbenzylammonium chlorate, led to a great increase of the conductivity of PLA/DMF solutions, so that the average fiber diameter of the electrospun PLA fibers decreased dramatically from 500 nm to 100-200 nm. The addition of surfactant, Span-80, did not improve the fiber morphology but formed beaded fiber web.
研究了通过静电纺丝制备的直径小于200nm的超细聚（D，L-丙交酯）（PLA）纤维，以获得类似于细胞外基质的组织修复材料。使用扫描电子显微镜观察纤维形态。结果表明，溶剂是决定静电纺PLA纤维形成的关键因素。与丙酮相比，N，N-二甲基甲酰胺（DMF）是PLA静电纺丝的更好溶剂。有机盐氯酸三乙基苄基铵的加入导致PLA/DMF溶液的电导率大幅增加，使得静电纺PLA纤维的平均纤维直径从500nm急剧下降到100-200nm。表面活性剂Span-80的加入并没有改善纤维形态，而是形成了珠状纤维网。
