De La Paz M A, Patrinely J R, Marines H M, Appling W D
Department of Ophthalmology, Baylor College of Medicine, Houston, Texas 77030.
Am J Ophthalmol. 1992 Aug 15;114(2):208-11. doi: 10.1016/s0002-9394(14)73986-8.
Survival is uncommon in bilateral cerebro-rhino-orbital mucormycosis treated surgically and medically. A 66-year-old man in previously good health had bilateral cerebro-rhino-orbital mucormycosis and newly diagnosed nonketotic diabetes mellitus at initial examination. Total loss of vision, proptosis, and ophthalmoplegia of both eyes were present. The patient was treated with aggressive surgical and medical therapies that included bilateral orbital exenteration, intravenous and local amphotericin B, hyperbaric oxygen, and control of the diabetes mellitus. One and one-half years after onset of the illness, the patient is alert and clinically stable. The importance of prompt diagnosis and aggressive treatment of this disease is emphasized by this case. Additionally, we suggest that adjunctive hyperbaric oxygen is a reasonable modality in the treatment of this often fatal disease.
双侧脑鼻眶毛霉菌病经手术和药物治疗后存活情况并不常见。一名66岁身体健康的男性在初诊时患有双侧脑鼻眶毛霉菌病及新诊断出的非酮症糖尿病。双眼出现完全失明、眼球突出及眼球运动麻痹。患者接受了积极的手术和药物治疗，包括双侧眼眶内容物剜除术、静脉及局部使用两性霉素B、高压氧治疗以及糖尿病控制。发病一年半后，患者神志清醒且临床状况稳定。该病例强调了对此疾病进行及时诊断和积极治疗的重要性。此外，我们建议辅助高压氧治疗是治疗这种常致命疾病的一种合理方式。
