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Chromosomal imbalances in nasopharyngeal carcinoma: a meta-analysis of comparative genomic hybridization results.

作者信息

Li Xin, Wang Ena, Zhao Ying-dong, Ren Jia-Qiang, Jin Ping, Yao Kai-Tai, Marincola Francesco M

机构信息

Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

J Transl Med. 2006 Jan 19;4:4. doi: 10.1186/1479-5876-4-4.

DOI:10.1186/1479-5876-4-4
PMID:16423296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1403800/
Abstract

Nasopharyngeal carcinoma (NPC) is a highly prevalent disease in Southeast Asia and its prevalence is clearly affected by genetic background. Various theories have been suggested for its high incidence in this geographical region but to these days no conclusive explanation has been identified. Chromosomal imbalances identifiable through comparative genomic hybridization may shed some light on common genetic alterations that may be of relevance to the onset and progression of NPC. Review of the literature, however, reveals contradictory results among reported findings possibly related to factors associated with patient selection, stage of disease, differences in methodological details etc. To increase the power of the analysis and attempt to identify commonalities among the reported findings, we performed a meta-analysis of results described in NPC tissues based on chromosomal comparative genomic hybridization (CGH). This meta-analysis revealed consistent patters in chromosomal abnormalities that appeared to cluster in specific "hot spots" along the genome following a stage-dependent progression.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea6/1403800/bbb58684fc78/1479-5876-4-4-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea6/1403800/f3a03532c8f0/1479-5876-4-4-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea6/1403800/882a9884064b/1479-5876-4-4-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea6/1403800/f0757974a790/1479-5876-4-4-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea6/1403800/e10ffdd324ba/1479-5876-4-4-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea6/1403800/bbb58684fc78/1479-5876-4-4-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea6/1403800/f3a03532c8f0/1479-5876-4-4-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea6/1403800/882a9884064b/1479-5876-4-4-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea6/1403800/f0757974a790/1479-5876-4-4-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea6/1403800/e10ffdd324ba/1479-5876-4-4-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea6/1403800/bbb58684fc78/1479-5876-4-4-5.jpg

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基于生物信息学分析的鼻咽癌中与ceRNA网络相关关键基因的综合分析
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