Taniguchi Ataru, Fukushima Mitsuo, Ohya Michihiro, Nakai Yoshikatsu, Yoshii Satoru, Nagasaka Shoichiro, Matsumoto Kazunari, Taki Yoshiro, Kuroe Akira, Nishimura Fusanori, Seino Yutaka
Division of Diabetes and Clinical Nutrition, Kansai-Denryoku Hospital, Osaka 553-0003, Japan.
Metabolism. 2006 Feb;55(2):258-62. doi: 10.1016/j.metabol.2005.08.020.
The aim of the present study was to investigate the relationships between interleukin 6 (IL-6) and insulin resistance, serum leptin, serum adiponectin, or serum lipids including triglycerides in 98 nonobese Japanese type 2 diabetic patients. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). Serum IL-6 concentration was negatively correlated to high-density lipoprotein cholesterol (r = -0.295, P = .004), but was not associated with HOMA-IR (r = 0.016, P = .871), body mass index (BMI) (r = 0.090, P = .375), systolic (r = 0.169, P = .116) and diastolic (r = -0.061, P = .570) blood pressures, leptin (r = 0.062, P = .544), and adiponectin (r = -0.020, P = .841) in these patients. In contrast, serum leptin level was positively correlated to HOMA-IR (r = 0.291, P = .004), BMI (r = 0.338, P < .001), and systolic blood pressure (r = 0.241, P = .025). Serum adiponectin level was negatively correlated to HOMA-IR (r = -0.288, P = .005), BMI (r = -0.308, P = .002), diastolic blood pressure (r = -0.269, P = .012), and triglycerides (r = -0.338, P < .001), and positively correlated to high-density lipoprotein cholesterol (r = 0.300, P = .003) in our patients. From these results, it can be suggested that fasting serum IL-6 is not a major factor responsible for the evolution of insulin resistance in nonobese Japanese type 2 diabetic patients.
本研究旨在调查98例非肥胖日本2型糖尿病患者中白细胞介素6（IL-6）与胰岛素抵抗、血清瘦素、血清脂联素或包括甘油三酯在内的血脂之间的关系。胰岛素抵抗通过稳态模型评估（HOMA-IR）的胰岛素抵抗指数来估计。血清IL-6浓度与高密度脂蛋白胆固醇呈负相关（r = -0.295，P = .004），但与HOMA-IR（r = 0.016，P = .871）、体重指数（BMI）（r = 0.090，P = .375）、收缩压（r = 0.169，P = .116）和舒张压（r = -0.061，P = .570）、瘦素（r = 0.062，P = .544）以及脂联素（r = -0.020，P = .841）均无关联。相比之下，血清瘦素水平与HOMA-IR（r = 0.291，P = .004）、BMI（r = 0.338，P < .001）和收缩压（r = 0.241，P = .025）呈正相关。血清脂联素水平与HOMA-IR（r = -0.288，P = .005）、BMI（r = -0.308，P = .002）、舒张压（r = -0.269，P = .012）和甘油三酯（r = -0.338，P < .001）呈负相关，与高密度脂蛋白胆固醇呈正相关（r = 0.300，P = .003）。从这些结果可以推测，空腹血清IL-6并非非肥胖日本2型糖尿病患者胰岛素抵抗发展的主要因素。
