Kispert J F, Kazmers A, Roitman L
Vascular Surgery Service, University of Kentucky, Lexington.
Am Surg. 1992 Aug;58(8):491-5.
This study determined utility of preoperative spirometry for prediction of postoperative pulmonary complications (PPC) defined as pneumonia, ventilator dependence greater than 48 hours, and adult respiratory distress syndrome in 147 patients undergoing vascular surgery from June 1988 through March 1990 [39 aortic aneurysm repairs, 21 carotid procedures, and 87 operations for occlusive disease including aorto-ileofemoral, infra-inguinal, and visceral]. The incidence of PPC was 12.9 per cent, while cardiac complications (myocardial infarction, congestive heart failure, and ventricular arrhythmias) were present in 9.8 per cent. Prior or current smoking, which was present in 80 per cent, was not predictive of PPC. FEV1 was 2.2 +/- 0.7 L/s (mean +/- 1 SD). Abnormal FEV1 (2.0 or less L/s) was present in 42 per cent (n = 62). For FEV1 of 2.0 or less, PPC rate was 22.5 per cent versus 5.8 per cent for FEV1 greater than 2.0 L/s (P less than 0.005, Fisher exact). The incidence of PPC was 30.7 per cent for aortic aneurysm repair, 8.0 per cent for occlusive disease, and 4.7 per cent for carotid procedures. Abdominal aortic procedures (performed in 67 patients: 39 for aortic aneurysm repair and 28 for aortoiliac occlusive disease) were associated with a PPC rate of 22.4 per cent versus 5.0 per cent for "nonabdominal" procedures (P less than 0.002, Fisher exact). Life table analysis after surgery demonstrated decreased survival for patients with PPC (P = 0.031, Mantel-Haensel) during follow-up (250 +/- 165 days). PPC are associated with abnormal FEV1 and abdominal vascular procedures. In conclusion, preoperative spirometry is useful for the prediction of PPC after vascular surgery.
本研究确定了术前肺活量测定法对预测术后肺部并发症(PPC)的作用,术后肺部并发症定义为肺炎、呼吸机依赖超过48小时以及成人呼吸窘迫综合征。研究对象为1988年6月至1990年3月期间接受血管手术的147例患者[39例主动脉瘤修复术、21例颈动脉手术以及87例闭塞性疾病手术,包括主动脉-髂股动脉、腹股沟下动脉及内脏手术]。PPC的发生率为12.9%,而心脏并发症(心肌梗死、充血性心力衰竭和室性心律失常)的发生率为9.8%。80%的患者有既往或当前吸烟史,但这并非PPC的预测因素。第1秒用力呼气量(FEV1)为2.2±0.7升/秒(均值±1标准差)。42%(n = 62)的患者FEV1异常(≤2.0升/秒)。FEV1≤2.0时,PPC发生率为22.5%,而FEV1>2.0升/秒时为5.8%(P<0.005,Fisher确切概率法)。主动脉瘤修复术的PPC发生率为30.7%,闭塞性疾病手术为8.0%,颈动脉手术为4.7%。腹部主动脉手术(67例患者接受该手术:39例为主动脉瘤修复术,28例为主-髂动脉闭塞性疾病手术)的PPC发生率为22.4%,而“非腹部”手术为5.0%(P<0.002,Fisher确切概率法)。术后生存分析表明,随访期间(250±165天)发生PPC的患者生存率降低(P = 0.031,Mantel-Haensel法)。PPC与FEV1异常及腹部血管手术相关。总之,术前肺活量测定法有助于预测血管手术后的PPC。