Messroghli Daniel R, Plein Sven, Higgins David M, Walters Kevin, Jones Timothy R, Ridgway John P, Sivananthan Mohan U
BHF Cardiac MRI Unit, Leeds General Infirmary, England.
Radiology. 2006 Mar;238(3):1004-12. doi: 10.1148/radiol.2382041903. Epub 2006 Jan 19.
A prospective study approved by the local ethics committee was performed to establish the normal range and reproducibility of myocardial T1 values as assessed with single-breath-hold T1 mapping with high spatial resolution. With a 1.5-T magnetic resonance (MR) imaging system, baseline and contrast material-enhanced modified Look-Locker inversion recovery, or MOLLI, imaging was performed in 15 healthy volunteers who had given written informed consent. Image quality scores and myocardial T1 values were derived for standard short-axis segments and sections. Results were compared with those from a second MR imaging study performed on the same day (baseline only) and those from a third study performed on a different day (baseline and contrast enhanced; eight volunteers). Intra- and interobserver agreement were determined. Myocardial T1 maps were obtained rapidly in a reproducible fashion. A normal range for baseline and postcontrast myocardial T1 was established (baseline mean T1 in short-axis sections, 980 msec +/- 53 [standard deviation]; 95% confidence interval: 964, 997; number of sections, 43). This technique could enable direct quantification of changes in tissue characteristics in ischemic and inflammatory myocardial diseases.
一项经当地伦理委员会批准的前瞻性研究开展，旨在确定采用具有高空间分辨率的单次屏气T1mapping评估心肌T1值的正常范围和可重复性。使用1.5-T磁共振（MR）成像系统，对15名签署了书面知情同意书的健康志愿者进行了基线及对比剂增强的改良Look-Locker反转恢复（MOLLI）成像。获取了标准短轴节段和层面的图像质量评分及心肌T1值。将结果与同一天进行的第二项MR成像研究（仅基线）以及不同日期进行的第三项研究（基线和对比剂增强；8名志愿者）的结果进行比较。确定了观察者内和观察者间的一致性。以可重复的方式快速获得了心肌T1图谱。建立了基线及对比剂注射后心肌T1的正常范围（短轴层面的基线平均T1，980毫秒±53[标准差]；95%置信区间：964,997；层面数量，43）。该技术能够直接量化缺血性和炎症性心肌疾病中组织特征的变化。
