Eggimann Philippe, Oddo Mauro, Voirol Pierre, Zanetti Giorgio, Chioléro René
Soins intensifs de chirurgie, Département de chirurgie, CHUV, Lausanne.
Rev Med Suisse. 2005 Dec 14;1(45):2928-32.
Antibiotics are widely used in critical care and adequate empirical treatments has a significant impact on the outcome of many patients. Most nosocomial infections may be due to multidrug-resistant pathogens and requires empirical borad spectrum coverage before identification of the etiologic agents. This is associated with overuse of antibiotics which contributes to the further increase in multidrug-resistances. In this context, new strategies targeted at antibiotic control, such as guidelines and de-escalation are needed to control this evolution.
抗生素在重症监护中广泛使用，充分的经验性治疗对许多患者的预后有重大影响。大多数医院感染可能是由多重耐药病原体引起的，在确定病原体之前需要经验性的广谱覆盖。这与抗生素的过度使用有关，而抗生素的过度使用又导致多重耐药性进一步增加。在这种情况下，需要新的抗生素控制策略，如指南和降阶梯治疗，以控制这种演变。
