Carbajal D, Molina V, Mas R, Arruzazabala M L
Center for Natural Products of the National Center for Scientific Research, Havana City, Cuba.
Drugs Exp Clin Res. 2005;31(5-6):193-7.
Benign prostatic hyperplasia (BPH) is a nonmalignant growth of prostate leading to difficulty in urinating. Drug therapy, phytotherapy included, is frequently used to treat BPH. D-004 is a lipid extract from Roystonea regia fruits, and previous studies have shown that oral treatment with D-004 for 14 days prevented prostate hyperplasia (PH) induced by testosterone in rats. No information is available, however; about the effects of D-004 in reverting already established PH. This study investigated whether D-004 could improve PH after oral dosing with testosterone in rats. Rats were distributed in five groups (10 rats/group). One group was injected with soy oil (negative control) and four groups were injected with testosterone: one was orally treated with the vehicle (positive control), two with D-004 (200 and 400 mg/kg) and the other with Saw palmetto (400 mg/kg). At study completion, the rats were sacrificed and the prostates were removed and weighed. D-004 (200 and 400 mg/kg) significantly and dose-dependently decreased prostate enlargement by 85% and 98%, respectively, versus the positive control. Likewise, Saw palmetto (400 mg/kg) significantly reduced prostate weight by 73% versus the positive control. D-004 (400 mg/kg) was more effective (p < 0.05) than Saw palmetto (400 mg/kg) in lowering prostate enlargement. D-004 and Saw palmetto also decreased the prostate weight to body weight ratio, but did not affect body weight. In conclusion, D-004 (200 and 400 mg/kg) orally administered was effective for reducing PH after testosterone dosing. D-004 (400 mg/kg) was more effective than Saw palmetto (400 mg/kg). Further studies, however, are needed to corroborate the present results.
良性前列腺增生（BPH）是前列腺的一种非恶性生长，会导致排尿困难。药物治疗，包括植物疗法，经常用于治疗BPH。D - 004是从王棕果实中提取的脂质提取物，先前的研究表明，大鼠口服D - 004 14天可预防由睾酮诱导的前列腺增生（PH）。然而，关于D - 004对已形成的PH的逆转作用尚无相关信息。本研究调查了大鼠口服睾酮后D - 004是否能改善PH。大鼠分为五组（每组10只）。一组注射大豆油（阴性对照），四组注射睾酮：一组口服赋形剂（阳性对照），两组分别口服D - 004（200和400 mg/kg），另一组口服锯叶棕（400 mg/kg）。在研究结束时，处死大鼠并取出前列腺称重。与阳性对照相比，D - 004（200和400 mg/kg）分别显著且剂量依赖性地使前列腺肿大减少了85%和98%。同样，与阳性对照相比，锯叶棕（400 mg/kg）使前列腺重量显著降低了73%。在减轻前列腺肿大方面，D - 004（400 mg/kg）比锯叶棕（400 mg/kg）更有效（p < 0.05）。D - 004和锯叶棕还降低了前列腺重量与体重的比值，但不影响体重。总之，口服D - 004（200和400 mg/kg）对降低睾酮给药后的PH有效。D - 004（400 mg/kg）比锯叶棕（400 mg/kg）更有效。然而，需要进一步的研究来证实目前的结果。
