Somunkiran A, Yazici B, Demirci F, Erdogmus B, Ozdemir I
Abant Izzet Baysal University, Duzce Medical School, Department of Obstetrics and Gynecology, Konuralp, Duzce, Turkey.
Climacteric. 2006 Feb;9(1):59-65. doi: 10.1080/13697130500505223.
The aim of this prospective study was to evaluate the effects of tibolone on carotid atherosclerosis in healthy postmenopausal women.
Twenty-five healthy postmenopausal women were included in the study. Patients received tibolone 2.5 mg daily for 6 months. Resistance indices of the common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA) and vertebral arteries, and intima-media thickness of the CCA were measured both at baseline and at the end of the study with ultrasonography.
No significant differences were observed in the resistance indices of the CCA, ICA, ECA and vertebral arteries, as well as intima-media thickness of CCA at 6 months in comparison with baseline. Tibolone significantly improved the intima-media thickness of the CCA of women who were less than 18 months since menopause.
Overall, these results demonstrate no significant effects of tibolone on either intima-media thickness or blood flow resistance in the carotid arteries in postmenopausal women. However, the results suggest that tibolone may have a positive effect on the vascular system if commenced within 18 months since menopause; this warrants further investigation.
本前瞻性研究旨在评估替勃龙对健康绝经后女性颈动脉粥样硬化的影响。
25名健康绝经后女性纳入本研究。患者每日服用替勃龙2.5毫克，共6个月。在基线期和研究结束时，均采用超声检查测量颈总动脉（CCA）、颈内动脉（ICA）、颈外动脉（ECA）和椎动脉的阻力指数，以及CCA的内膜中层厚度。
与基线期相比，6个月时CCA、ICA、ECA和椎动脉的阻力指数以及CCA的内膜中层厚度均未观察到显著差异。替勃龙显著改善了绝经后18个月以内女性的CCA内膜中层厚度。
总体而言，这些结果表明替勃龙对绝经后女性颈动脉的内膜中层厚度或血流阻力均无显著影响。然而，结果提示，如果在绝经后18个月内开始使用替勃龙，可能对血管系统有积极作用；这值得进一步研究。
