Sham J S, Wei W I, Lau S K, Yau C C, Choy D
Department of Radiotherapy and Oncology, University of Hong Kong and Queen Mary Hospital, Hong Kong.
Arch Otolaryngol Head Neck Surg. 1992 Aug;118(8):794-7. doi: 10.1001/archotol.1992.01880080016005.
In a prospective study of 271 new patients with nasopharyngeal carcinoma, 36 (13.3%) were found to have cranial nerve involvement. Serous otitis media (SOM) was found in 98 (41.4%) of 237 patients who had undergone complete otologic assessment. The local control of tumor and actuarial survival of three subgroups of patients, namely, 80 patients with SOM only, 11 patients with cranial nerve palsy only, and 18 patients with both SOM and cranial nerve palsy, were analyzed. The local control of tumor was better in patients with SOM alone than in those with cranial nerve palsy alone; those patients with both SOM and cranial nerve involvement had worse local control as well as survival. As SOM is not uncommon in the diagnosis of nasopharyngeal carcinoma, and adult-onset SOM is otherwise distinctly uncommon, this provides a good opportunity for early recognition and, perhaps, better control of nasopharyngeal carcinoma.
在一项针对271例新发鼻咽癌患者的前瞻性研究中，发现36例（13.3%）存在颅神经受累。在237例接受了全面耳科评估的患者中，98例（41.4%）发现有浆液性中耳炎（SOM）。分析了三组患者的肿瘤局部控制情况和精算生存率，这三组分别为：仅患有SOM的80例患者、仅患有颅神经麻痹的11例患者以及同时患有SOM和颅神经麻痹的18例患者。单纯患有SOM的患者的肿瘤局部控制情况优于单纯患有颅神经麻痹的患者；同时患有SOM和颅神经受累的患者的局部控制情况以及生存率更差。由于SOM在鼻咽癌诊断中并不罕见，而成人期SOM在其他情况下则明显不常见，这为早期识别以及或许更好地控制鼻咽癌提供了一个良好的机会。
