Toft P, Tønnesen E, Svendsen P, Rasmussen J W, Christensen N J
Department of Anaesthesiology, Odense University Hospital, Copenhagen, Denmark.
APMIS. 1992 Jul;100(7):593-7.
Adrenergic activation is known to occur in sepsis and after major surgery or trauma. An elevated serum concentration of adrenaline is followed by lymphocytosis in peripheral blood even in splenectomized patients. The purpose of the present study was to clarify the redistribution of lymphocytes in the tissues during adrenaline infusion. Lymphocytes were isolated from 24 rabbits, labelled with indium-111-tropolone and reinjected into the rabbits. The next day the rabbits were anaesthetized. Eight rabbits received 3 micrograms of adrenaline i.v. followed by 0.2 micrograms/min, eight received 300 micrograms of adrenaline i.v. followed by 20 micrograms/min, while eight received a saline infusion and served as a control group. The activity of labelled cells was imaged with a gamma camera and computer before, during and after adrenaline infusion. The activity of the spleen decreased to 90% and 94% of initial values during low and high doses of adrenaline. The activity of the bone marrow decreased to 91% and 96%, respectively, while the activity of the heart/lung and the liver increased to 107% and 106% with the high dose of adrenaline. In peripheral blood the lymphocytes increased 10%. It is concluded that lymphocytes are redistributed from spleen and bone marrow to peripheral blood, lungs and liver during adrenaline infusion in this animal model.
已知在脓毒症以及大手术或创伤后会发生肾上腺素能激活。即使是脾切除患者，外周血中血清肾上腺素浓度升高后也会出现淋巴细胞增多。本研究的目的是阐明肾上腺素输注期间淋巴细胞在组织中的重新分布情况。从24只兔子中分离淋巴细胞，用铟 - 111 - 托酚酮标记后再注入兔子体内。第二天将兔子麻醉。8只兔子静脉注射3微克肾上腺素，随后以0.2微克/分钟的速度输注；8只兔子静脉注射300微克肾上腺素，随后以20微克/分钟的速度输注；另外8只兔子输注生理盐水作为对照组。在肾上腺素输注前、输注期间和输注后，用γ相机和计算机对标记细胞的活性进行成像。在低剂量和高剂量肾上腺素输注期间，脾脏的活性分别降至初始值的90%和94%。骨髓的活性分别降至91%和96%，而高剂量肾上腺素输注时，心脏/肺和肝脏的活性分别增加到107%和106%。外周血中的淋巴细胞增加了10%。得出的结论是，在该动物模型中，肾上腺素输注期间淋巴细胞从脾脏和骨髓重新分布到外周血、肺和肝脏。
