肠炎沙门氏菌鼠伤寒血清型ompS1和ompS2突变体在小鼠中的毒力减弱。
Salmonella enterica serovar Typhimurium ompS1 and ompS2 mutants are attenuated for virulence in mice.
作者信息
Rodríguez-Morales Olivia, Fernández-Mora Marcos, Hernández-Lucas Ismael, Vázquez Alejandra, Puente José Luis, Calva Edmundo
机构信息
Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca, Morelos 62210, México.
出版信息
Infect Immun. 2006 Feb;74(2):1398-402. doi: 10.1128/IAI.74.2.1398-1402.2006.
Abstract
Salmonella enterica serovar Typhimurium mutants with mutations in the ompS1 and ompS2 genes, which code for quiescent porins, were nevertheless highly attenuated for virulence in a mouse model, indicating a role in pathogenesis. Similarly, a strain with a mutation in the gene coding for LeuO, a positive regulator of ompS2, was also attenuated.
摘要
编码静态孔蛋白的ompS1和ompS2基因发生突变的肠炎沙门氏菌鼠伤寒血清型突变体，在小鼠模型中其毒力仍显著减弱，这表明它们在发病机制中发挥作用。同样，编码ompS2的正向调节因子LeuO的基因发生突变的菌株也表现出毒力减弱。
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