Taylor P W
CIBA-Geigy Pharmaceuticals, Horsham, UK.
Exp Clin Immunogenet. 1992;9(1):48-56.
Exposure of gram-negative bacteria to a source of antibody and complement frequently results in efficient cell killing; this effect follows the deposition of C5b-9 membrane attack complexes onto the bacterial surface. This review examines the molecular and physiological events culminating in C5b-9 deposition and cell death and advances an hypothesis that may account for cytoplasmic-membrane damage following complement-mediated perturbation of the outer membrane.
革兰氏阴性菌暴露于抗体和补体来源时，常常会导致有效的细胞杀伤；这种效应是在C5b - 9膜攻击复合物沉积到细菌表面之后出现的。本综述研究了最终导致C5b - 9沉积和细胞死亡的分子和生理事件，并提出了一个假说，该假说可能解释补体介导的外膜扰动后细胞质膜的损伤。
