萘烷型拟乙酰胆碱有机磷酸酯作为乙酰胆碱酯酶抑制剂
Decalin-type acetylcholine-mimetic organophosphates as inhibitors of acetylcholinesterase.
作者信息
Furegati Stefan, Gorla Fabrizio, Linden Anthony, Rüedi Peter
机构信息
Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
出版信息
Chem Biol Interact. 2005 Dec 15;157-158:415-7. doi: 10.1016/j.cbi.2005.10.084.
The novel decalin-type N,O,P-heterocycles, P(3)-axially and P(3)-equatorially substituted cis- and trans-configurated 3-fluoro-2,4-dioxa-7-aza-, 2,4-dioxa-8-aza-, and 2,4-dioxa-9-aza-3-phosphabicyclo[4.4.0]decane 3-oxides, are configuratively fixed and conformationally constrained phosphorus analogues of acetylcholine. The compounds are suitable probes for the investigation of molecular interactions with acetylcholinesterase.
新型十氢化萘型N、O、P杂环，即P(3)轴向和P(3)赤道向取代的顺式和反式构型的3-氟-2,4-二氧杂-7-氮杂-、2,4-二氧杂-8-氮杂-和2,4-二氧杂-9-氮杂-3-磷杂双环[4.4.0]癸烷3-氧化物，是构象固定且构象受限的乙酰胆碱磷类似物。这些化合物是用于研究与乙酰胆碱酯酶分子相互作用的合适探针。
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