Kumamoto H
Division of Oral Pathology, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, Sendai, Japan.
J Oral Pathol Med. 2006 Feb;35(2):65-74. doi: 10.1111/j.1600-0714.2006.00380.x.
Odontogenic tumors are lesions derived from the elements of the tooth-forming apparatus and are found exclusively within the jawbones. This review represents a contemporary outline of our current understanding of the molecular and genetic alterations associated with the development and progression of odontogenic tumors, including oncogenes, tumor-suppressor genes, oncoviruses, growth factors, telomerase, cell cycle regulators, apoptosis-related factors, regulators of tooth development, hard tissue-related proteins, cell adhesion molecules, matrix-degrading proteinases, angiogenic factors, and osteolytic cytokines. It is hoped that better understanding of related molecular mechanisms will help to predict the course of odontogenic tumors and lead to the development of new therapeutic concepts for their management.
牙源性肿瘤是源自牙齿形成器官成分的病变，仅见于颌骨内。本综述概述了我们目前对与牙源性肿瘤发生和进展相关的分子和基因改变的认识，包括癌基因、肿瘤抑制基因、致癌病毒、生长因子、端粒酶、细胞周期调节因子、凋亡相关因子、牙齿发育调节因子、硬组织相关蛋白、细胞粘附分子、基质降解蛋白酶、血管生成因子和溶骨细胞因子。希望对相关分子机制的更好理解将有助于预测牙源性肿瘤的病程，并推动开发新的治疗理念来管理这些肿瘤。
