人类系统性红斑狼疮中白细胞介素-2的转录抑制
Transcriptional repression of interleukin-2 in human systemic lupus erythematosus.
作者信息
Katsiari Christina G, Tsokos George C
机构信息
Dept. of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20190, USA.
出版信息
Autoimmun Rev. 2006 Feb;5(2):118-21. doi: 10.1016/j.autrev.2005.08.009. Epub 2005 Sep 26.
PMID:16431340
Abstract
T cells from patients with SLE produce decreased amounts of interleukin-2 (IL-2), a central cytokine in the regulation of the immune response. We discuss herein the abnormalities underlying IL-2 deficiency in SLE T cells.
摘要
系统性红斑狼疮（SLE）患者的T细胞产生的白细胞介素-2（IL-2）量减少，IL-2是免疫反应调节中的一种关键细胞因子。我们在此讨论SLE T细胞中IL-2缺乏的潜在异常情况。
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