Yasmeen Riffat, Shoaib M Harris, Khalid Halima
Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.
Pak J Pharm Sci. 2005 Jan;18(1):47-51.
Tablets are the most common dosage form. Tablets can be prepared by dry method and wet methods, both methods have their own significance as well as disadvantages. Dry method and particularly direct compression is most simplest method of tablet manufacturing. On the other hand granulation is a multiple processing method which add complexity and make validation and control difficult. For comparative study of atenolol tablets a new formulation was designed and compressed by direct compression method. Then it's physical parameters including hardness, friability, diameter, thickness, disintegration time, dissolution test were performed and finally assay carried out for evaluation and characterization of this new formulation against other formulation available in the market.
片剂是最常见的剂型。片剂可通过干法和湿法制备，两种方法都有其自身的意义和缺点。干法，尤其是直接压片是片剂生产最简单的方法。另一方面，制粒是一种多步骤的方法，增加了复杂性，使验证和控制变得困难。为了对阿替洛尔片剂进行比较研究，设计了一种新的制剂并通过直接压片法进行压制。然后对其物理参数进行了测定，包括硬度、脆碎度、直径、厚度、崩解时间、溶出度测试，最后进行含量测定，以评估和表征这种新制剂相对于市场上其他制剂的性能。
