Reding R
Pediatric Liver Transplant Program, Saint-Luc University Clinics, Université catholique de Louvain, Brussels, Belgium.
Acta Gastroenterol Belg. 2005 Oct-Dec;68(4):453-6.
Liver transplantation (LT) today constitutes a well-standardized and efficient therapy for children with acute and chronic hepatic failure. Appropriate pre-transplant management, organ preservation, adequate surgical techniques, and the progressive introduction of new immunosuppressive regimens have contributed to significantly improve, over the years, the general outcome after LT. Consequently, these good overall results has allowed the constitution of a growing cohort of children, adolescents and young adults submitted to chronic immunosuppression. The long-term complications of immunosuppression administered to transplant recipients include the adverse effects secondary to the depression of the immune system, the toxicities specifically related to the individual immunosuppressive drugs, and the sense of lack of rehabilitation for the transplant patient, with, secondarily, the question of non-adherence to the medications. This review will essentially focus on these three issues in the particular context of pediatric liver transplantation.
如今，肝移植（LT）已成为治疗急性和慢性肝衰竭儿童的一种标准化且高效的疗法。多年来，适当的移植前管理、器官保存、足够的手术技术以及新免疫抑制方案的逐步引入，显著改善了肝移植后的总体预后。因此，这些良好的总体结果使得接受慢性免疫抑制治疗的儿童、青少年和年轻人的队列不断扩大。移植受者接受免疫抑制治疗的长期并发症包括免疫系统抑制继发的不良反应、与个别免疫抑制药物相关的毒性，以及移植患者缺乏康复感，其次还有不坚持服药的问题。本综述将主要关注小儿肝移植这一特定背景下的这三个问题。
