β,β'-四甲基取代的十六烷二酸（MEDICA 16）对蛋鸡生产性能和蛋黄脂质组成的影响。

Effect of beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16) on laying hen performance and egg yolk lipid composition.

Elkin R G, Rogler J C, Lee H D, Watkins B A

Department of Animal Sciences, Purdue University, West Lafayette, Indiana 47907.

Br Poult Sci. 1992 Jul;33(3):677-81. doi: 10.1080/00071669208417506.

Abstract

beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16), an inhibitor of hepatic cholesterogenesis and lipogenesis in rats, was orally administered to 24-week-old White Leghorn hens for a period of 16 d. Hens were fed maize-soya-bean meal diets containing 0, 1.5, or 3.0 g MEDICA 16/kg. 2. Although MEDICA 16 did not affect egg weight, yolk weight, egg cholesterol content, or the efficiency of food utilisation, egg production was significantly reduced in birds fed 3.0 g MEDICA 16/kg compared to those fed the other two diets. 3. Total yolk monounsaturated fatty acids were significantly higher in eggs of hens fed both inclusion rates of MEDICA 16 compared to those of the control birds. In contrast, egg yolk total polyunsaturated fatty acid content and the ratio of polyunsaturated to saturated fatty acids were both inversely related to the dietary content of MEDICA 16. 4. These results suggest that MEDICA 16 primarily altered hepatic fatty acid metabolism, but not cholesterol synthesis, in laying hens.

摘要

将β,β'-四甲基取代的十六烷二酸（MEDICA 16，一种大鼠肝脏胆固醇生成和脂肪生成的抑制剂）口服给予24周龄的白来航蛋鸡，持续16天。给蛋鸡饲喂含有0、1.5或3.0克MEDICA 16/千克的玉米-豆粕日粮。2. 尽管MEDICA 16不影响蛋重、蛋黄重、蛋胆固醇含量或食物利用效率，但与饲喂其他两种日粮的蛋鸡相比，饲喂3.0克MEDICA 16/千克的蛋鸡产蛋量显著降低。3. 与对照蛋鸡相比，饲喂两种MEDICA 16添加率的蛋鸡蛋黄中总单不饱和脂肪酸显著更高。相反，蛋黄中总多不饱和脂肪酸含量以及多不饱和脂肪酸与饱和脂肪酸的比例均与MEDICA 16的日粮含量呈负相关。4. 这些结果表明，MEDICA 16主要改变了产蛋鸡肝脏脂肪酸代谢，但未改变胆固醇合成。