Chow Hak-Fun, Ng Ka-Fai, Wang Zhao-Yang, Wong Chun-Ho, Luk To, Lo Chui-Man, Yang Yu-Ying
Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR.
Org Lett. 2006 Feb 2;8(3):471-4. doi: 10.1021/ol0526928.
[structure: see text]. A new series of amphiphilic G1-G3 dendrons containing purely aliphatic hydrocarbon dendritic surface sectors and one or two carboxylic acid group(s) at the focal point was synthesized in good yields. The key branching steps involve diallylation reactions of diethyl malonate or Meldrum's acid. These dendrons are highly soluble in hexane despite having highly polar carboxylic acid groups at the focal point.
[结构：见原文]。合成了一系列新型两亲性G1-G3树枝状分子，其具有纯脂肪烃树枝状表面部分，且在焦点处含有一个或两个羧酸基团，产率良好。关键的分支步骤涉及丙二酸二乙酯或丙二酸亚异丙酯的二烯丙基化反应。尽管这些树枝状分子在焦点处具有高极性的羧酸基团，但它们在己烷中高度可溶。
