Beryozkina Tetyana, Appukkuttan Prasad, Mont Nuria, Van der Eycken Erik
Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Heverlee, Belgium.
Org Lett. 2006 Feb 2;8(3):487-90. doi: 10.1021/ol052766f.
[reaction: see text]. A novel, microwave-enhanced, highly efficient protocol for the synthesis of hitherto unknown (-)-steganacin and (-)-steganone 7-aza analogues containing a 1,2,3-triazole ring has been presented. Microwave irradiation was found to be highly beneficial in promoting the Suzuki reaction and the 1,3-dipolar cycloaddition reaction to generate the highly strained medium-sized ring system of the title molecules.
