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单独或与阿莫西林联合使用克拉霉素对肺炎链球菌进行脉冲给药。

Pulsatile delivery of clarithromycin alone or in combination with amoxicillin against Streptococcus pneumoniae.

作者信息

Leuthner Kimberly D, Cheung Chrissy M, Rybak Michael J

机构信息

Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.

出版信息

Antimicrob Agents Chemother. 2006 Feb;50(2):813-6. doi: 10.1128/AAC.50.2.813-816.2006.

DOI:10.1128/AAC.50.2.813-816.2006
PMID:16436754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1366876/
Abstract

We evaluated pulsatile dosing of clarithromycin and amoxicillin alone or combined against Streptococcus pneumoniae with various susceptibilities. When combined, pulsatile amoxicillin with clarithromycin was superior to either 8- or 12-h dosing against the intermediate strain and was identical for the susceptible strain. Pulse dosing of antimicrobials warrants further investigation.

摘要

我们评估了单独使用或联合使用克拉霉素和阿莫西林的脉冲给药方案对不同敏感性肺炎链球菌的疗效。联合使用时，脉冲给药的阿莫西林与克拉霉素对中度敏感菌株的疗效优于8小时或12小时给药方案，对敏感菌株的疗效相同。抗菌药物的脉冲给药值得进一步研究。

相似文献

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Antimicrob Agents Chemother. 2006 Feb;50(2):813-6. doi: 10.1128/AAC.50.2.813-816.2006.
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本文引用的文献

1
Efficacy of pulsatile amoxicillin and clarithromycin dosing alone and in combination in a murine pneumococcal pneumonia model.脉冲式给药的阿莫西林和克拉霉素单独及联合使用在小鼠肺炎球菌肺炎模型中的疗效
J Antimicrob Chemother. 2005 Sep;56(3):559-65. doi: 10.1093/jac/dki261. Epub 2005 Jul 15.
2
Pharmacodynamics of cefepime alone and in combination with various antimicrobials against methicillin-resistant Staphylococcus aureus in an in vitro pharmacodynamic infection model.在体外药效学感染模型中，头孢吡肟单独及与多种抗菌药物联合对耐甲氧西林金黄色葡萄球菌的药效学研究
Antimicrob Agents Chemother. 2005 Jan;49(1):302-8. doi: 10.1128/AAC.49.1.302-308.2005.
3
Pulsatile delivery of amoxicillin against Streptococcus pneumoniae.阿莫西林对肺炎链球菌的脉冲式给药。
J Antimicrob Chemother. 2004 Dec;54(6):1067-71. doi: 10.1093/jac/dkh452. Epub 2004 Oct 14.
4
Application of pharmacokinetics and pharmacodynamics to antimicrobial therapy of respiratory tract infections.药代动力学和药效学在呼吸道感染抗菌治疗中的应用。
Clin Lab Med. 2004 Jun;24(2):477-502. doi: 10.1016/j.cll.2004.03.009.
5
In-vitro model for simultaneous simulation of the serum kinetics of two drugs with different half-lives.用于同时模拟两种半衰期不同药物血清动力学的体外模型。
J Antimicrob Chemother. 1985 Jan;15 Suppl A:125-30. doi: 10.1093/jac/15.suppl_a.125.