Treiber Carina
Freie Universitaet Berlin, Thielallee 63, 14195 Berlin, Germany.
Sci Aging Knowledge Environ. 2006 Jan 25;2006(4):pe4. doi: 10.1126/sageke.2006.4.pe4.
Prion diseases for the most part affect individuals older than 60 years of age and share features with other diseases characterized by protein deposits in the brain, such as Alzheimer's disease and Parkinson's disease. The international conference "Prion 2005: Between Fundamentals and Society's Needs," organized by the German Transmissible Spongiform Encephalopathies Research Platform, aimed to integrate and coordinate the research efforts of participants to better achieve prevention, treatment, control, and management of prion diseases, including Creutzfeldt-Jakob disease and fatal familial insomnia in humans. Several main topics were discussed, such as the molecular characteristics of prion strains, the cell biology of cellular and pathogenic forms of the prion proteins, the pathogenesis of the diseases they cause, emerging problems, and promising approaches for therapy and new diagnostic tools. The presentations at the Prion 2005 conference provided new insights in both basic and applied research, which will have broad implications for society's needs.
朊病毒疾病大多影响60岁以上的人群，并且与其他以大脑中蛋白质沉积为特征的疾病具有共同特点，如阿尔茨海默病和帕金森病。由德国传染性海绵状脑病研究平台组织的“2005年朊病毒：基础研究与社会需求之间”国际会议，旨在整合和协调参与者的研究工作，以更好地实现朊病毒疾病的预防、治疗、控制和管理，包括人类的克雅氏病和致死性家族性失眠症。会议讨论了几个主要议题，如朊病毒株的分子特征、朊病毒蛋白的细胞形式和致病形式的细胞生物学、它们所引起疾病的发病机制、新出现的问题以及有前景的治疗方法和新的诊断工具。2005年朊病毒会议上的报告在基础研究和应用研究方面都提供了新的见解，这将对社会需求产生广泛影响。
