谷氨酰胺对化疗患者肠道屏障功能的保护作用

[Protective effect of glutamine on intestinal barrier function in patients receiving chemotherapy].

作者信息

Jiang Hai-ping, Liu Chun-an

机构信息

Department of General Surgery, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.

出版信息

Zhonghua Wei Chang Wai Ke Za Zhi. 2006 Jan;9(1):59-61.

PMID:16437375

Abstract

OBJECTIVE

To study the protective effect of glutamine (Gln) on intestinal permeability in patients receiving chemotherapy.

METHODS

Thirty-nine patients with gastrointestinal cancer after operation were randomly divided into Gln and control groups, and received oral administration of glutamine (30 g/d) for 7 days (n=22) or not (n=17). All patients received CF+ 5-FU chemotherapy for 5 days. Serum concentration of glutamine and urinary lactulose/mannitol (L/M) ratio were measured before and 1 day after chemotherapy.

RESULTS

After chemotherapy, the serum Gln concentration was significantly decreased to (535.42+/- 53.75) micromol/L in the control group and increased to (54.44+/- 81.26) micromol/L in the Gln group, and there was significant difference between the two groups (P< 0.01). Urine L/M ratio was significantly increased to (0.0453+/- 0.0078) in the control group and decreased to (0.0331+/- 0.0061) in the Gln group, and there was significant difference between the two groups after chemotherapy (P< 0.01).

CONCLUSION

Oral administration of glutamine granules can increase serum concentration of glutamine in chemotherapy patients with gastrointestinal cancer and can decrease intestinal permeability, maintain intestinal barrier.

摘要

目的

研究谷氨酰胺（Gln）对接受化疗患者肠道通透性的保护作用。

方法

39例胃肠道癌术后患者随机分为谷氨酰胺组和对照组，分别给予口服谷氨酰胺（30 g/d）7天（n = 22）或不给予（n = 17）。所有患者均接受CF + 5 - FU化疗5天。化疗前及化疗后1天测定血清谷氨酰胺浓度和尿乳果糖/甘露醇（L/M）比值。

结果

化疗后，对照组血清Gln浓度显著降至（535.42±53.75）μmol/L，谷氨酰胺组升至（54.44±81.26）μmol/L，两组间差异有统计学意义（P < 0.01）。对照组尿L/M比值显著升至（0.0453±0.0078），谷氨酰胺组降至（0.0331±0.0061），化疗后两组间差异有统计学意义（P < 0.01）。