Miner Edward C, Miller Wayne L
Department of Internal MedicineMayo Clinic College of Medicine, Rochester, Minn 55905, USA.
Mayo Clin Proc. 2006 Jan;81(1):71-6. doi: 10.4065/81.1.71.
The extracellular matrix (ECM) of the heart dynamically interacts with various cellular components of the myocardium, including the myocytes and connective tissue cells. With the development and progression of heart failure, left ventricular (LV) myocardial remodeling occurs. The progression of LV remodeling is accompanied by alterations in the structure and function of the ECM that occur after injury resulting from neurohormonal activation, changes in LV loading conditions, and alterations in myocardial perfusion and metabolism and is secondary to a host of nonmyocyte signaling pathways that affect repair and remodeling of the myocardium as a whole. This article attempts to review some of these processes and their interactions and to provide a focus to the often overlooked contribution of the ECM to the development and progression of heart failure and thereby its potential role as a target for therapy for heart failure.
心脏的细胞外基质（ECM）与心肌的各种细胞成分动态相互作用，包括心肌细胞和结缔组织细胞。随着心力衰竭的发展和进展，左心室（LV）心肌发生重塑。LV重塑的进展伴随着ECM结构和功能的改变，这些改变发生在神经激素激活、LV负荷条件变化、心肌灌注和代谢改变所导致的损伤之后，并且继发于一系列影响整个心肌修复和重塑的非心肌细胞信号通路。本文试图综述其中的一些过程及其相互作用，并聚焦于ECM对心力衰竭发展和进展的贡献，而这一贡献常常被忽视，从而阐述其作为心力衰竭治疗靶点的潜在作用。
