Angers Rachel C, Browning Shawn R, Seward Tanya S, Sigurdson Christina J, Miller Michael W, Hoover Edward A, Telling Glenn C
Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA.
Science. 2006 Feb 24;311(5764):1117. doi: 10.1126/science.1122864. Epub 2006 Jan 26.
The emergence of chronic wasting disease (CWD) in deer and elk in an increasingly wide geographic area, as well as the interspecies transmission of bovine spongiform encephalopathy to humans in the form of variant Creutzfeldt Jakob disease, have raised concerns about the zoonotic potential of CWD. Because meat consumption is the most likely means of exposure, it is important to determine whether skeletal muscle of diseased cervids contains prion infectivity. Here bioassays in transgenic mice expressing cervid prion protein revealed the presence of infectious prions in skeletal muscles of CWD-infected deer, demonstrating that humans consuming or handling meat from CWD-infected deer are at risk to prion exposure.
慢性消耗病（CWD）在鹿和麋鹿中出现在越来越广泛的地理区域，以及牛海绵状脑病以变异型克雅氏病的形式跨物种传播给人类，引发了人们对CWD人畜共患病潜力的担忧。由于食用肉类是最有可能的接触途径，因此确定患病鹿科动物的骨骼肌是否含有朊病毒传染性至关重要。在此，对表达鹿科动物朊病毒蛋白的转基因小鼠进行的生物测定显示，感染CWD的鹿的骨骼肌中存在传染性朊病毒，这表明食用或处理感染CWD的鹿肉的人有接触朊病毒的风险。
