Hu Jen Jan, Lu Chun Yi, Chang Luan Yin, Huang Chin Hao, Chou Chen Cheng, Huang Fu Yuan, Lee Chin Yun, Huang Li Min
Department of Pediatrics, Taiwan Adventist Hospital, Taipei, Taiwan.
J Microbiol Immunol Infect. 2006 Feb;39(1):54-8.
Pertussis is an acute respiratory tract illness resulting from Bordetella pertussis. Widespread use of pertussis vaccine over the past 50 years has decreased the incidence of pertussis. The incidence of pertussis in adolescents and adults has increased in many areas of the world. This study aimed to evaluate the etiologic role of B. pertussis in patients with prolonged cough in Taiwan.
Patients with cough lasting for more than 1 week were recruited. Nasopharyngeal swabs were taken for culture of B. pertussis and detection of nucleic acid of B. pertussis by polymerase chain reaction. Serum samples were collected in a subset of patients for assay of immunoglobulin G and immunoglobulin A antibodies against pertussis toxin.
In total, 111 patients were recruited. Thirty-three patients agreed to have their serum samples taken and tested. Eight patients had evidence of acute infection with B. pertussis; among them, 1 was diagnosed by polymerase chain reaction and 7 by serology. Older subjects were more likely to suffer from pertussis than younger subjects. The incidence of pertussis in patients with prolonged cough was 7.2%. However, the rate could have been as high as 21% in those with serum samples tested.
We conclude that pertussis is a prevalent disease in Taiwan, especially in adolescents and adults.
百日咳是由百日咳博德特氏菌引起的急性呼吸道疾病。在过去50年中，百日咳疫苗的广泛使用降低了百日咳的发病率。在世界许多地区，青少年和成人百日咳的发病率有所上升。本研究旨在评估百日咳博德特氏菌在台湾持续性咳嗽患者中的病因学作用。
招募咳嗽持续超过1周的患者。采集鼻咽拭子用于百日咳博德特氏菌培养，并通过聚合酶链反应检测百日咳博德特氏菌核酸。在部分患者中采集血清样本，检测抗百日咳毒素的免疫球蛋白G和免疫球蛋白A抗体。
共招募了111例患者。33例患者同意采集并检测血清样本。8例患者有百日咳博德特氏菌急性感染的证据；其中，1例通过聚合酶链反应确诊，7例通过血清学确诊。年龄较大的受试者比年龄较小的受试者更容易患百日咳。持续性咳嗽患者中百日咳的发病率为7.2%。然而，在检测血清样本的患者中，这一比例可能高达21%。
我们得出结论，百日咳在台湾是一种常见疾病，尤其是在青少年和成人中。
